|
KMID : 0816119990020010046
|
|
Korean Journal of Pediatric Gastroenterolology and Nutrition
1999 Volume.2 No. 1 p.46 ~ p.58
|
|
|
Evaluation of the Underlying Etiology and Long-Term Prognostic Factors in Neonatal Cholestasis
|
|
Kim Kyung-Mo
Seo Jeong-Kee
|
|
|
Abstract
|
|
|
Purpose : The aim of the present study was to evaluate the long-term clinical profile
including the underlying etioligy and the prognostic factors of the neonatal cholestasis.
Method : We studied the 190 infants presented with neonatal cholestasis for the last
12 years (from 1981 to 1992). The underlying causes, clinical findings and long-term
outcomes were evaluated. And the prognostic factors were also analyzed.
Result : Underlying disease were neonatal hepatitis in 101 (idiopathic in 77 and
infectious in 24), intrahepatic bile duct paucity in 5, biliary atresia in 79, choledochal
cyst in 5. Metabolic disease was not observed in this study. The important clinical
problems during follow-up were persistent high fever, gastrointestinal bleeding, hepatic
encephalopathy and ascites. The main causes of the death were hepatic encephalopathy
and gastrointestinal bleeding. While three fourth of infants with idiopathic and infectious
neonatal hepatitis recovered usually within a year, five-year survival rate for biliary
atresia was just 40%, the mortality observed usually within the first year after Kasai
operation and prognostic factor was the time of operation. Underlying disease was the
most important prognostic factor of neonatal cholestasis.
Conclusion : This study showed that most common causes of neonatal cholestasis
were biliary atresia and idiopathic neonatal hepatitis, infectious neonatal hepatitis,
choledochal cyst and Alagille syndrome, but few neonatal cholestasis of genetic or
metabolic liver disease was observed. The most important long-term prognostic factor of
neonatal cholestasis was the underlying disease.
|
|
|
KEYWORD
|
|
|
Neonatal cholestasis, Neonatal hepatitis, Biliary atresia, Prognosis, Prognostic factor,
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
  
|
|